Estimation of COVID-19 spread curves integrating global data and borrowing information

Currently, novel coronavirus disease 2019 (COVID-19) is a big threat to global health. The rapid spread of the virus has created pandemic, and countries all over the world are struggling with a surge in COVID-19 infected cases. There are no drugs or other therapeutics approved by the US Food and Drug Administration to prevent or treat COVID-19: information on the disease is very limited and scattered even if it exists. This motivates the use of data integration, combining data from diverse sources and eliciting useful information with a unified view of them. In this paper, we propose a Bayesian hierarchical model that integrates global data for real-time prediction of infection trajectory for multiple countries. Because the proposed model takes advantage of borrowing information across multiple countries, it outperforms an existing individual country-based model. As fully Bayesian way has been adopted, the model provides a powerful predictive tool endowed with uncertainty quantification. Additionally, a joint variable selection technique has been integrated into the proposed modeling scheme, which aimed to identify possible country-level risk factors for severe disease due to COVID-19

Molecular basis for heat desensitization of TRPV1 ion channels.

The transient receptor potential vanilloid 1 (TRPV1) ion channel is a prototypical molecular sensor for noxious heat in mammals. Its role in sustained heat response remains poorly understood, because rapid heat-induced desensitization (Dh) follows tightly heat-induced activation (Ah). To understand the physiological role and structural basis of Dh, we carried out a comparative study of TRPV1 channels in mouse (mV1) and those in platypus (pV1), which naturally lacks Dh. Here we show that a temperature-sensitive interaction between the N- and C-terminal domains of mV1 but not pV1 drives a conformational rearrangement in the pore leading to Dh. We further show that knock-in mice expressing pV1 sensed heat normally but suffered scald damages in a hot environment. Our findings suggest that Dh evolved late during evolution as a protective mechanism and a delicate balance between Ah and Dh is crucial for mammals to sense and respond to noxious heat

ZegCLIP: Towards Adapting CLIP for Zero-shot Semantic Segmentation

Recently, CLIP has been applied to pixel-level zero-shot learning tasks via a two-stage scheme. The general idea is to first generate class-agnostic region proposals and then feed the cropped proposal regions to CLIP to utilize its image-level zero-shot classification capability. While effective, such a scheme requires two image encoders, one for proposal generation and one for CLIP, leading to a complicated pipeline and high computational cost. In this work, we pursue a simpler-and-efficient one-stage solution that directly extends CLIP's zero-shot prediction capability from image to pixel level. Our investigation starts with a straightforward extension as our baseline that generates semantic masks by comparing the similarity between text and patch embeddings extracted from CLIP. However, such a paradigm could heavily overfit the seen classes and fail to generalize to unseen classes. To handle this issue, we propose three simple-but-effective designs and figure out that they can significantly retain the inherent zero-shot capacity of CLIP and improve pixel-level generalization ability. Incorporating those modifications leads to an efficient zero-shot semantic segmentation system called ZegCLIP. Through extensive experiments on three public benchmarks, ZegCLIP demonstrates superior performance, outperforming the state-of-the-art methods by a large margin under both "inductive" and "transductive" zero-shot settings. In addition, compared with the two-stage method, our one-stage ZegCLIP achieves a speedup of about 5 times faster during inference. We release the code at https://github.com/ZiqinZhou66/ZegCLIP.git.Comment: 12 pages, 8 figure